Effect of CpG-DNA inclusion in pH-sensitive polymer-liposome vaccines on their immune-inducing activities

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pH-sensitive liposomes: acid-induced liposome fusion.

Sonicated unilamellar liposomes containing phosphatidylethanolamine and palmitoylhomocysteine fuse rapidly when the medium pH is lowered from 7 to 5. Liposome fusion was demonstrated by (i) mixing of the liposomal lipids as shown by resonance energy transfer, (ii) gel filtration, and (iii) electron microscopy. The pH-sensitive fusion of liposomes was observed only when palmitoylhomocysteine (gr...

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ژورنال

عنوان ژورنال: Frontiers in Bioengineering and Biotechnology

سال: 2016

ISSN: 2296-4185

DOI: 10.3389/conf.fbioe.2016.01.01226